Seizures. If you have any seizures while taking Procrit, get medical help right away and tell your healthcare provider. There are reports of at least 33 pregnant women with anemia alone or anemia associated with severe renal disease and other hematologic disorders who received Procrit. Polyhydramnios and intrauterine growth restriction were reported in women with chronic renal disease, which is associated with an increased risk for these adverse pregnancy outcomes. There was 1 infant born with pectus excavatum and hypospadias following exposure during the first trimester. Due to the limited number of exposed pregnancies and multiple confounding factors such as underlying maternal conditions, other maternal medications, and gestational timing of exposure these published case reports and studies do not reliably estimate the frequency or absence of adverse outcomes.
Use this medication 4 times a day or as directed by your doctor. It may take from several days to several months to complete treatment. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Dosage is based on your medical condition and response to therapy. Protect Procrit from light. If you miss a dose, use it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Consult your doctor or pharmacist about how you can such as eating a diet high in fiber, drinking plenty of water. PROCRIT-treated patients in clinical studies were nausea, vomiting, pruritus, headache, injection site pain, chills, deep vein thrombosis, cough, and hypertension. Single-dose vials of Procrit should be used only one time. Throw the vial away after use even if there is medicine left in the vial.
Prior to treatment, inform patients of the risks and benefits of Procrit. What do I need to know about the different types of Procrit vials? Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. What is a subcutaneous injection? Use these Instructions for Use if you or your caregiver has been trained to give Procrit injections at home. Do not give yourself the injection unless you have received training from your healthcare provider. If you are not sure about giving the injection or you have questions, ask your healthcare provider for help.
Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure. This discharge may happen days before or at the start of labor. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Narrator: Could there be a relationship between sleep position and your personality? It is important to dispose of the needles and syringes correctly. Do not throw needles into the trash. You may receive a hard plastic container made especially for used syringes and needles. You can also use a soda bottle or other plastic bottle with a screw lid. Make sure that both the syringe and needle fit into the container easily and cannot break through the sides. Ask your healthcare provider or a pharmacist what your state or local requirements are for getting rid of used syringes and needles. What are the risks of a subcutaneous injection? Take Procrit exactly as your healthcare provider tells you to. Do not change the dose of Procrit unless told to do so by your healthcare provider. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. This medication is given as an injection under the skin or into a vein as directed by your doctor, usually 1 to 3 times a week. Patients getting this medication before surgery may have a special dosing schedule. Hemodialysis patients should receive this medication by injection into a vein. Procrit is indicated for the treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy. For the best possible benefit, it is important to receive each scheduled dose of this as directed. If you miss a dose, contact your doctor or right away to establish a new dosing schedule. You may get an infection, have the needle break in your skin, or hit a nerve. You may have scarring, lumps, or dimpling of the skin from a subcutaneous injection. When should I contact a healthcare provider? Have any other medical conditions. Although normal therapeutic doses of this product deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known. Premature and low-birthweight infants, as well as patients receiving high dosages, may be more likely to develop toxicity. Practitioners administering this and other medications containing benzyl alcohol should consider the combined daily metabolic load of benzyl alcohol from all sources. Insert the needle with a quick motion into the pinched skin at a 90-degree angle straight up and down. The needle should be all the way into your skin.
If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. When drawing up a dose into a syringe, be sure to follow the procedure demonstrated to you to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers. Store at room temperature away from light and moisture. Different brands of this have different storage needs. Some medical conditions may interact with Procrit. Procrit is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Procrit at home, a health care provider will teach you how to use it. Be sure you understand how to use Procrit. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. This medicine may be harmful if swallowed.
This medication may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. In place of emergency treatment for anemia RBC transfusions. In addition, mean hemoglobin, hematocrit, and reticulocyte counts increased significantly during the presurgery period in patients treated with Procrit. Lack of zinc in the diet. When prealbumin levels are lower than normal, it may be a sign of a poor diet malnutrition. Your doctor may use the results of this test to make changes in your diet. He or she also may use the results to see how well or protein replacement fluids are working. PROCRIT is not indicated for use in patients undergoing cardiac or vascular surgery. For the overwhelming majority of people with iron deficiency, taking iron pills every day replaces the missing iron, and low blood counts return to normal. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding. Nurse: So, do you have any questions before I start putting all the wires on and give you an explanation?
This medication is injected once a day for 7 days in a row or as directed by your doctor. A 7-day course of this medication is called a cycle. This cycle is repeated every 4 weeks depending on your response and tests. Try to use the same general injection area at the same time of each day for example, use the for the injection before lunch. Note: The abdomen absorbs insulin the fastest, followed by the arms, thighs, and buttocks. It is not known whether this drug passes into milk. Thigh: Uncover the entire leg. Find the area halfway between the knee and hip and slightly to the side. Gently grasp the area to make sure you can pinch 1 to 2 inches of skin. Tell your doctor if your pain persists or worsens. Pull out the needle: Remove the needle at the same angle you put it in. Gently wipe the area with the gauze pad. Before use, clean the affected area with mild soap and water, rinse well, and pat dry. Store in the refrigerator. Do not freeze. Protect from light. Store the medication in the original carton until ready for use. Let the medication come to room temperature before using. For the single-use vials, discard any unused medication right away. For the multi-use vials, store opened vials in the refrigerator and discard any unused medication after 3 weeks. Keep all medications away from children and pets. PROCRIT, and use the lowest dose of PROCRIT sufficient to reduce the need for RBC transfusions. Keep this medicine in a safe place to prevent theft, misuse, or abuse. If someone accidentally swallows this drug, get medical help right away. Insert the needle into the skin: Hold the syringe barrel tightly and use your wrist to inject the needle into the skin. Once the needle is all the way in, push the plunger down to inject the medicine. Liquid products may contain sugar and alcohol. Keep Procrit away from light. Do not stop taking any medications without consulting your healthcare provider.
Do not put the needle cover back on the needle. Choose an injection site for your insulin shot. PROCRIT or placebo for 15 days. Food and Drug Administration FDA-approved class-wide update for erythropoiesis-stimulating agents ESAs. Serious allergic reactions, including anaphylactic reactions, angioedema, bronchospasm, skin rash, and urticaria may occur with PROCRIT. Immediately and permanently discontinue PROCRIT and administer appropriate therapy if a serious allergic or anaphylactic reaction occurs. Procrit, and use the lowest dose of Procrit sufficient to reduce the need for RBC transfusions. Advise the patient to read the FDA-approved patient labeling Medication Guide. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. RBC transfusions or significant reduction in zidovudine dose. Labeling Rule PLR and to the Medication Guide, which is part of the full prescribing information. The Medication Guide is a component of the ESA Risk Evaluation and Mitigation Strategy REMS. Roll the bottle of insulin between your hands two to three times to mix the insulin. Do not shake the bottle, as air bubbles can form and affect the amount of insulin withdrawn.
The pharmacokinetics of Procrit has not been studied in patients with HIV infection. Contact your doctor if you feel weak, lightheaded, or short of breath, or if your skin looks pale. These may be signs that your body has stopped responding to this medication. Take this medication by as directed by your doctor. You may take this drug with or without food. All patients received oral iron and appropriate pharmacologic anticoagulation therapy. Across all studies, 72 patients were treated with concomitant non cisplatin-containing chemotherapy regimens and 59 patients were treated with concomitant cisplatin-containing chemotherapy regimens. Twelve patients 19% in the epoetin alfa arm and 10 patients 15% in the placebo-arm dropped out prior to week 6 and are excluded from efficacy analyses. S1 and a comparative dosing study 2 dosing regimens, S2. Also, among darbepoetin alfa-treated subjects with a past history of cancer, there were more deaths due to all causes and more deaths adjudicated as due to cancer, in comparison with the control group. It is believed to work by helping your bone marrow grow normal so you will need fewer transfusions. Azacitidine also kills abnormal blood cells that have grown too fast and not work properly. The multiple-dose vials are formulated with benzyl alcohol. Do not administer Procrit from multiple-dose vials, or Procrit from single-dose vials admixed with bacteriostatic saline containing benzyl alcohol, to neonates or infants. Units of Procrit also contain sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrate.
The mouth, lips, or face swells after the injection is given. The pharmacokinetic profile of Procrit in children and adolescents appeared similar to that of adults. Due to increased risk of deep venous thrombosis DVT DVT prophylaxis is recommended. How do I get rid of used syringes and needles? Procrit and other ESAs increased the risk of death, myocardial infarction, stroke, congestive heart failure, thrombosis of hemodialysis vascular access, and other thromboembolic events in the higher target groups. Increased mortality was observed in a randomized, placebo-controlled study of Procrit in adult patients who were undergoing CABG surgery 7 deaths in 126 patients randomized to Procrit versus no deaths among 56 patients receiving placebo. Four of these deaths occurred during the period of study drug administration and all 4 deaths were associated with thrombotic events. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. For the combined Procrit treatment groups, a total of 90 25% and 268 75% women between the ages of 29 and 89 years were enrolled. As labor progresses, contractions become more regular, frequent, and intense, increasing to every seven to 10 minutes, then every five to seven minutes. Procrit-treated patients and remained unchanged in patients receiving placebo. Procrit-treated patients experienced improvements in exercise tolerance and patient-reported physical functioning at month 2 that were maintained throughout the study. Use this medication regularly to get the most benefit from it. To help you remember, use it on the same days of the week as directed. Do not shake. Do not use Procrit that has been shaken or frozen. The trial was terminated early with adverse safety findings of higher mortality in the high hematocrit target group. Keep all away from children and pets. Michael Breus, PhD, DABSM: CPAP is a small mask attached to an air compressor which pushes air down his throat allowing him to breathe all evening long. The name Procrit appears on the carton and vial label.
Mean hemoglobin levels were similar for the 2 treatment groups throughout the postsurgical period. If you experience shortness of breath, chest pain, or arm or leg swelling, contact your doctor immediately. Do not shake this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. If you are injecting this medication under the skin, before each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. This is given by injection under the or into a vein by a professional. Pull back on the plunger to the required number of units measure from the top of the plunger. There was no accumulation of serum erythropoietin after the 2 dosing regimens during the study period. Draw the required number of units of air into the syringe by pulling the plunger back. You need to draw the same amount of air into the syringe as insulin you need to inject. Always measure from the top of the plunger. In patients undergoing cardiac or vascular surgery. Tip of the Week: Are you ready for the baby? For patients who do not respond adequately over a 12-week escalation period, increasing the Procrit dose further is unlikely to improve response and may increase risks. Use the lowest dose that will maintain a hemoglobin level sufficient to reduce the need for RBC transfusions. Evaluate other causes of anemia. Discontinue Procrit if responsiveness does not improve. To read the Medication Guide. Procrit increases the reticulocyte count within 10 days of initiation, followed by increases in the RBC count, hemoglobin, and hematocrit, usually within 2 to 6 weeks. The rate of hemoglobin increase varies among patients and is dependent upon the dose of Procrit administered. The baby is getting rounder every day, and skin is getting pinker and losing its wrinkly appearance. Your baby's head is usually positioned down into the pelvis by now. Insert the needle into the rubber stopper of the insulin bottle. Push the plunger down to inject air into the bottle this allows the insulin to be drawn more easily. Leave the needle in the bottle. The multiple-dose vials of Procrit are formulated with benzyl alcohol. Do not administer Procrit from multiple-dose vials, or Procrit from single-dose vials admixed with bacteriostatic saline containing benzyl alcohol, to a nursing woman. Have had a serious allergic reaction to Procrit.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Ask your doctor or pharmacist about using this product safely. Do not shake Procrit. Shaking could cause Procrit not to work. If you shake Procrit, the solution in the vial may look foamy and should not be used. RBC transfusion-related risks is a goal. Protect vials from light. PROCRIT-treated patients in clinical studies were hypertension and arthralgia. Procrit is a prescription medicine used to treat anemia. People with anemia have a lower-than-normal number of RBCs. Procrit works like the human protein called erythropoietin to help your body make more RBCs. Procrit is used to reduce or avoid the need for RBC transfusions. Shake well before using, and use the provided dropper to carefully measure out the dose. Discard unused portions of Procrit in preservative-free vials. Do not re-enter preservative-free vials. The most common investigator-attributed cause of death within the first 4 months was disease progression; 28 of 41 deaths in the epoetin alfa arm and 13 of 16 deaths in the placebo arm were attributed to disease progression. Investigator-assessed time to tumor progression was not different between the 2 groups. Double-check that you have the correct dose in the syringe. Lay the vial down on its side with the needle still in it until after you have selected and prepared your site for injection. Do not use Procrit if it has been frozen.
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Among 778 patients enrolled in the 3 clinical studies of Procrit for the treatment of anemia due to concomitant chemotherapy, 419 received Procrit and 359 received placebo. Of the 419 who received Procrit, 247 59% were age 65 years and over, while 78 19% were 75 years and over. No overall differences in safety or effectiveness were observed between geriatric and younger patients. The dose requirements for Procrit in geriatric and younger patients within the 3 studies were similar. It is unknown what increases this risk. Streiff M, Holmstrom B, Ashrani Aetal. Rarely, using corticosteroid for a long time can make it more difficult for your body to respond to physical stress.
Other health problems also may cause your levels to drop. You may need another blood test to be sure that a poor diet is the reason for your low prealbumin levels. The full PROCRIT prescribing information, including Boxed WARNINGS, will be available at www. Do not dilute Procrit. Do not mix it with other solutions unless your doctor directs you otherwise.
Study C2 was conducted in 222 anemic patients, ages 5 to 18, receiving chemotherapy for the treatment of various childhood malignancies. To undergo regular blood pressure monitoring, adhere to prescribed anti-hypertensive regimen and follow recommended dietary restrictions. HIV infection receiving concomitant therapy with zidovudine. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Baby: Boys often tend to weigh a little more than girls. More lanugo falls out, but some may remain at birth on the baby's shoulders, folds of skin, and backs of ears. Avoid contact with people who have recently received live such as inhaled through the nose. Based on effective donor screening and product manufacturing processes, it carries an extremely remote risk for transmission of viral diseases. A theoretical risk for transmission of Creutzfeldt-Jakob disease CJD also is considered extremely remote. No cases of transmission of viral diseases or CJD have ever been identified for albumin. Because you will be injecting insulin on a regular basis for diabetes, you need to know where to inject it and how to rotate move your injection sites. By rotating your injection sites, you will make your injections easier, safer, and more comfortable. If the same injection site is used over and over again, you may develop hardened areas under the skin that keep the insulin from being used properly.